Two new Hebbian rules in vitro

Posted by Neville Sanjana at 12:57 AM EST

Mu-Ming Poo’s lab (which in 1998 found a very impressive result in hippocampal culture where excitatory synapses are potentiated when a Hebb-like protocol is used on the pre- and post-synaptic cell) has recently added two new Hebbian rules also found in hippocampal cell culture.

The first one applies to inhibitory hippocampal synapses (Neuron, Aug 2003) and the second one applies to spike trains in the mossy fiber pathway (Neuron, Feb 2004). The relative spike timing between the pre and post cells results in different amounts of potentiation/depression depending on the synapse type.

Some questions: Are there many different STDP rules? Or, are we missing the bigger picture (ie. a more general rule) of which these are all only specific examples? (Remember, this is just in hippocampus!)

4 Responses to “Two new Hebbian rules in vitro”

  1. Bayle Says:

    these links are broken

    see also the STDP section in http://dx.doi.org/10.1038/81453
    (figure 2)

  2. Andy Says:

    Hallo

  3. Mary Ellen Hebb Says:

    I am the daughter of Donald Hebb (of the “hebbian rule”). Would you be kind enough to give me your name(s) and a phone number (or, at least an email address) so I can get in touch with you?
    Thanks!

    Mary Ellen Hebb
    Toronto, Ontario

  4. Jackie Andrade Says:

    To Mary Ellen Hebb,

    I would like to reprint a portion of your father’s book on the Organization of Behavior and I understand you hold the copyright. Could you contact me please?

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