Comments on: Prozac leads to neurogenesis of neural progenitors http://neurodudes.com/2006/06/22/prozac-leads-to-neurogenesis-of-neural-progenitors/ at the intersection of neuroscience and AI. Sun, 07 Sep 2008 02:36:29 +0000 http://wordpress.org/?v=2.6 By: BilZ0r http://neurodudes.com/2006/06/22/prozac-leads-to-neurogenesis-of-neural-progenitors/#comment-5660 BilZ0r Wed, 05 Jul 2006 00:14:14 +0000 http://neurodudes.com/2006/06/22/prozac-leads-to-neurogenesis-of-neural-progenitors/#comment-5660 Yeah that science paper is fun allright, however, it has several problems, mainly that the test they used is a test of anxiety, not depression (it responds to benzo treatment) (and yes I know that studies have come out with learned helplessness and the same result). Also, BrdU is not neuron specific. And transcranial magnetic stimulation is generally antidepressant, but not proneurogenic. Just saying, that Science paper isn't the best science I've ever seen. Yeah that science paper is fun allright, however, it has several problems, mainly that the test they used is a test of anxiety, not depression (it responds to benzo treatment) (and yes I know that studies have come out with learned helplessness and the same result).

Also, BrdU is not neuron specific.

And transcranial magnetic stimulation is generally antidepressant, but not proneurogenic. Just saying, that Science paper isn’t the best science I’ve ever seen.

]]> By: Guest http://neurodudes.com/2006/06/22/prozac-leads-to-neurogenesis-of-neural-progenitors/#comment-5523 Guest Mon, 03 Jul 2006 04:28:10 +0000 http://neurodudes.com/2006/06/22/prozac-leads-to-neurogenesis-of-neural-progenitors/#comment-5523 Actually, this explanation has been around for at least 3 years. In the following paper, they showed that irradiation (which blocks neurogenesis) also cancels out the antidepressant effect - showing that it is likely to be more than an epiphenomenon: Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R. <a href="http://www.sciencemag.org/cgi/content/full/301/5634/805" rel="nofollow">Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.</a> Science. 2003 Aug 8;301(5634):805-9. Actually, this explanation has been around for at least 3 years. In the following paper, they showed that irradiation (which blocks neurogenesis) also cancels out the antidepressant effect - showing that it is likely to be more than an epiphenomenon:

Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R.
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants.
Science. 2003 Aug 8;301(5634):805-9.

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