Comments on: Damage to the insula might cure cigarette addiction http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/ at the intersection of neuroscience and AI. Fri, 29 Aug 2008 19:07:05 +0000 http://wordpress.org/?v=2.6 By: Ananda http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/#comment-38866 Ananda Wed, 07 Feb 2007 12:44:04 +0000 http://neurodudes.com/?p=355#comment-38866 In response to the first few entries, I wonder whether a bilateral insular lesion would have produced more dramatic results, somewhat similar to prosopagnosia being best obsereved in patients with bilat lesions. Since there are adequate animal models of addiction, this might be worth investigating and moving away from the emphasis on the septal/NA region. In response to the first few entries, I wonder whether a bilateral insular lesion would have produced more dramatic results, somewhat similar to prosopagnosia being best obsereved in patients with bilat lesions. Since there are adequate animal models of addiction, this might be worth investigating and moving away from the emphasis on the septal/NA region.

]]> By: Bayle http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/#comment-36051 Bayle Tue, 30 Jan 2007 01:44:24 +0000 http://neurodudes.com/?p=355#comment-36051 Hello, Lou, I'm glad to hear that you liked it. You already know more about dopamine receptors in the insula than I do. Perhaps another reader can provide more information though. Also, would you like to post the references you have already found? You could post another comment, or, if you'd like, you can even post that as a main article -- just follow the instructions under "how to post" at the top-right hand side of the page at http://neurodudes.com. Thanks, bayle Hello, Lou, I’m glad to hear that you liked it. You already know more about dopamine receptors in the insula than I do. Perhaps another reader can provide more information though. Also, would you like to post the references you have already found? You could post another comment, or, if you’d like, you can even post that as a main article — just follow the instructions under “how to post” at the top-right hand side of the page at http://neurodudes.com. Thanks,
bayle

]]> By: Lou Alvis http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/#comment-35987 Lou Alvis Mon, 29 Jan 2007 21:07:33 +0000 http://neurodudes.com/?p=355#comment-35987 As a student of addiction,i have read much on the importance of the dopamine uptake relationship noted in many addictive materials, mostly plant based alkaloids or their man made equivalents. Nicotine falls into this category, though apperently without the large dopamine receptor die off noted in users of methamphetamine and cocaine. I have noted some papers with references to dopamine (d2 ) receptor in the anterior insula, and some references to novelty seeking and receptors on the right side of the insula. perhaps you could suggest some further reading on these relationships? I also want to thank you for the excelent graphic presentation of the statistical results of Dr. Navqui's study.such graphics are very usefull in education. Thank you for you time and I am delighted to have found your site and service. L Alvis As a student of addiction,i have read much on the importance of the dopamine uptake relationship noted in many addictive materials, mostly plant based alkaloids or their man made equivalents. Nicotine falls into this category, though apperently without the large dopamine receptor die off noted in users of methamphetamine and cocaine. I have noted some papers with references to dopamine (d2 ) receptor in the anterior insula, and some references to novelty seeking and receptors on the right side of the insula. perhaps you could suggest some further reading on these relationships? I also want to thank you for the excelent graphic presentation of the statistical results of Dr. Navqui’s study.such graphics are very usefull in education. Thank you for you time and I am delighted to have found your site and service.
L Alvis

]]> By: Bayle http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/#comment-35664 Bayle Sun, 28 Jan 2007 08:04:35 +0000 http://neurodudes.com/?p=355#comment-35664 Hi Nasir, it's neat to have the author of the article responding to one's weblog entry! I share your opinion that a larger sample size would probably have achieved significance, I hope my entry didn't give another impression. Thanks for the review, I added it to the entry. I missed it because the word "insula" wasn't in the title. Incidentally, since the insula seems to be a rather big, do you have any hunches as to which area of the insula might be most involved? Hi Nasir, it’s neat to have the author of the article responding to one’s weblog entry! I share your opinion that a larger sample size would probably have achieved significance, I hope my entry didn’t give another impression. Thanks for the review, I added it to the entry. I missed it because the word “insula” wasn’t in the title.

Incidentally, since the insula seems to be a rather big, do you have any hunches as to which area of the insula might be most involved?

]]> By: Nasir Naqvi http://neurodudes.com/2007/01/25/damage-to-the-insula-might-cure-cigarette-addiction/#comment-35572 Nasir Naqvi Sun, 28 Jan 2007 01:52:33 +0000 http://neurodudes.com/?p=355#comment-35572 I am the author of this study. I read your take with interest. You correctly point out that insula-lesioned patients were more likely to, but not significantly so. I suspect that if we had a larger sample size this would have been significant. If you are interested in a review of insula function, I suggest Bud Craig's 2002 Nature Reviews Neuroscience review. We think that the visceral sensory functions of the insula are key because of the visceral effects of smoking, such as effects in the airway and cardiovascular systems. I am the author of this study. I read your take with interest. You correctly point out that insula-lesioned patients were more likely to, but not significantly so. I suspect that if we had a larger sample size this would have been significant. If you are interested in a review of insula function, I suggest Bud Craig’s 2002 Nature Reviews Neuroscience review. We think that the visceral sensory functions of the insula are key because of the visceral effects of smoking, such as effects in the airway and cardiovascular systems.

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