neurodudes

Ed strikes again!
Two-Color, Bi-Directional Optical Voltage Control of Genetically-Targeted Neurons

Having found a powerful method for activating neurons with blue light in the protein Channelrhodopsin-2 (ChR2) [1], we sought to augment the toolbox by finding a single-component system capable of mediating light-elicited neuronal inhibition. We identified a powerful tool, the mammalian codon-optimized version of the light-driven chloride pump halorhodopsin, from the archaebacterium Natronobacterium pharaonis (here abbreviated Halo) [2].

This entry was posted on Friday, March 9th, 2007 at 11:40 pm by Neville Sanjana and is filed under Genetics and molecular, Ion channels, Methods & techniques, Multi-electode arrays. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.