neurodudes

Transcranial magnetic stimulation (TMS) is a popular technology for stimulating human cortical neurons, due to its safety, noninvasiveness, and efficacy. A TMS device is just a little coil of wire, through which 10,000 Amps of current is cranked during a period of only a few hundred microseconds; the resultant rapidly-changing magnetic field induces eddy currents in the brain. Depending on the protocol used, TMS can drive/inhibit a region of cortex corresponding to roughly a cubic centimeter or two, and is being explored for the treatment of depression, the reduction of auditory hallucinations during schizophrenia, and the alleviation of tinnitus and migraines. Thousands of papers on medicine and psychology have been written using this tool.

Yet the device itself is expensive and rare — they can run from $20,000 to $50,000 or even more, despite the fact that they are, in essence, a coil, a switch, a bank of capacitors, and a power supply. Much of the art lies in making the devices safe and fail-proof. Is it possible to hack/engineer a system that is safe, fault-tolerant, efficacious, and inexpensive? And furthermore, can we facilitate a community that will devise such devices, and share information about protocols and approaches to brain hacking?

This past August at Foo Camp, a hackers’ conference in Northern California, a group of people got together and set out to do just that. We are designing a safe, noninvasive, modular, and “open source” brain stimulator that will open up the field of circuit modulation to a wider audience. Members of the group include therapists and mental health professionals, engineers, programmers, and others interested in either the development of such devices, or the sharing of information on this front. Key to the design is safety — we want to make sure that the devices we create are as safe as devices on the market. Also, all the information is released under the Creative Commons “Attribution and Sharealike” license. This is a new model for “open source” medical device development — which may move it beyond the domain of simply creating “cool toys,” and to creating real devices.

You can find out more information, or contribute to the project, or learn from the project, at
http://transcenmentalism.org/OpenStim/

-Ed

My website “Quad Nets: Device Models of Brains” is online at www.quadnets.com.
(link)

“Quad Nets” proposes a new kind of “artificial intelligence” that uses devices other than computers. Chiefly presented through Images, the Quad Net approach integrates physics, neuroscience and psychology in primal forms, initially rudimentary, but suitable for unlimited development in size and complexity.

I am an amateur and have privately worked in these areas for many years. Unfortunately, I have not found a means of communication through established channels. I hope that the readers of this blog will provide needed critical review. Thanks to the “neurodudes” for making this medium available.

Bob Kovsky (rlk “at” sonic.net)

In the provocative-hypothesis-of-the-week department:

Kevin Lafferty, a parasitologist, has put forth the idea that a fairly ubiquitous parasite (infecting O(10%) of Americans, and up to 2/3 of people in places like Brazil) is responsible for some of the diversity of human culures (1). The parasite uses common housecats to increase its transmission to the next host in the life cycle, and has a subtle effect on human personality, with some studies claiming that it even causes neuroticism, and even schizophrenia. (One clinical report (2) claims that “subjects with latent toxoplasmosis had higher intelligence [and] lower guilt proneness.” Hmm!)

Anyway, Lafferty noted that toxoplasmosis varies in prevalence from world region to world region, and then tries to draw correlates between these prevalences and local cultures:

“Drivers of the geographical variation in the prevalence of this parasite include the effects of climate on the persistence of infectious stages in soil, the cultural practices of food preparation and cats as pets. Some variation in culture, therefore, may ultimately be related to how climate affects the distribution of T. gondii, though the results only explain a fraction of the variation in two of the four cultural dimensions, suggesting that if T. gondii does influence human culture, it is only one among many factors.”

I wonder how one could test this hypothesis? Look for recent immigrants from one culture to another, who have lower Toxoplasmosis incidence? (Preferably finding populations that go in opposite directions, as a control.) Track culture change vs. migration vs. climate change?

Unlikely, perhaps. But nice that people are still thinking big

– Ed

(1) Lafferty, K
Can the common brain parasite, Toxoplasma gondii, influence human culture?
Proceedings of the Royal Society B: Biological Sciences
doi:10.1098/rspb.2006.3641

Picked up by the popular press here

(2) Flegr J, Havlicek J.
Changes in the personality profile of young women with latent toxoplasmosis.
Folia Parasitol (Praha). 1999;46(1):22-8.

A New Psychology resource, community built by psychologists and trainees, to unify the body of psychology information in one place:

http://psychology.wikia.com/wiki/Main_Page

Check it out, and if it interests you, please contribute, or review it on your blog.

Tom Michael, Mostly Zen – site admin

This past May, the Almaden Research center, part of IBM research, invited some provocative speakers on the topic of “Cognitive Computing” to come and speak. Since IBM recently invested a lot of money into understanding the brain with the Blue Brain project, it seems like this meeting was a way to figure out the next step along this path.

Powerpoint presentations and videos of the event are available online.

From the synopsis:

The 2006 Almaden Institute will focus on the theme of “Cognitive Computing” and will examine scientific and technological issues around the quest to understand how the human brain works. We will examine approaches to understanding cognition that unify neurological, biological, psychological, mathematical, computational, and information-theoretic insights. We focus on the search for global, top-down theories of cognition that are consistent with known bottom-up, neurobiological facts and serve to explain a broad range of observed cognitive phenomena. The ultimate goal is to understand how and when can we mechanize cognition.

Confirmed speakers include Toby Berger (Cornell), Gerald Edelman (The Neurosciences Institute), Joaquin Fuster (UCLA), Jeff Hawkins (Palm/Numenta), Robert Hecht-Nielsen (UCSD), Christof Koch (CalTech), Henry Markram (EPFL/BlueBrain), V. S. Ramachandran (UCSD), John Searle (UC Berkeley) and Leslie Valiant (Harvard). Confirmed panelists include: James Albus (NIST), Theodore Berger (USC), Kwabena Boahen (Stanford), Ralph Linsker (IBM), and Jerry Swartz (The Swartz Foundation).

Backs to the Future

Cool stuff:

New analysis of the language and gesture of South America’s indigenous Aymara people indicates a reverse concept of time.

Contrary to what had been thought a cognitive universal among humans – a spatial metaphor for chronology, based partly on our bodies’ orientation and locomotion, that places the future ahead of oneself and the past behind – the Amerindian group locates this imaginary abstraction the other way around: with the past ahead and the future behind.

Appearing in the current issue of the journal Cognitive Science, the study is coauthored, with Berkeley linguistics professor Eve Sweetser, by Rafael Nunez, associate professor of cognitive Science and director of the Embodied Cognition Laboratory at the University of California, San Diego.

On Making the Right Choice: The Deliberation-Without-Attention Effect — Dijksterhuis et al. 311 (5763): 1005 — Science

I don’t know quite what to make of this. In fact, I just don’t understand what is going on. But I can definitely think of examples from my own life where this is true. Sometimes not thinking about a problem really does lead to its solution and it’s fascinating to think about why this may be.

Also, the authors draw a connection between what they call unconscious thought (as performed in their experiments) and insights that can come “after sleeping on it”; I’m not sure these phenomena are the same. I think sleep taps into deeper organization processes that are not available on the timescale of unconscious thought, as given in the experiment.

Abstract:

Contrary to conventional wisdom, it is not always advantageous to engage in thorough conscious deliberation before choosing. On the basis of recent insights into the characteristics of conscious and unconscious thought, we tested the hypothesis that simple choices (such as between different towels or different sets of oven mitts) indeed produce better results after conscious thought, but that choices in complex matters (such as between different houses or different cars) should be left to unconscious thought. Named the “deliberation-without-attention” hypothesis, it was confirmed in four studies on consumer choice, both in the laboratory as well as among actual shoppers, that purchases of complex products were viewed more favorably when decisions had been made in the absence of attentive deliberation.

Last year, the Redwood Center for Theoretical Neuroscience moved from the Redwood Neuroscience Institute in Meno Park to the Helen Wills Neuroscience Institute at Berkeley. In October they held a symposium with several interesting speakers presenting on various topics within Theoretical Neuroscience.

The videos are now online for your perusal, or you can buy a DVD of the whole symposium for a paltry $5.

• Horace Barlow, Cambridge University: The Roles of Theory, Commonsense, and Guesswork in Neuroscience
• Dan Kersten, University of Minnesota: Human Object Perception: Theory, Psychophysics & Imaging
• Sue Becker, McMaster University: The role of the hippocampus in memory, contextual gating, stress and depression
• Florentin Worgotter, University of Goettingen: Learning in Neurons and Robots
• Panel Discussion: The Role and Future Prospects for Math/Computational Theories in Neuroscience
• David Heeger, New York University: What fMRI Can Tell Us about How Visual Cortex Works
• Kevan Martin, ETH/UNI Zurich: Canonical Circuits for Neocortex
• Terry Sejnowski, Salk Institute: Dendritic Darwinism
• Jeff Hawkins, Numenta: Prospects and Problems of Cortical Theory

A forthcoming issue of the journal Neuroscience is devoted to an examination of multidisciplinary approaches to the study of working memory within the field of Cognitive Neuroscience. Although the issue will not be released until late April, a detailed press release is available from the University of Washington at St. Louis.

From the article:

“Multidisciplinary research within cognitive neuroscience has established itself as a promising approach to answering the question of how the mind emerges from the working of the brain” [...] “One of the fields that has gained substantially by successfully combining the theoretical frameworks, methodologies, empirical results and insights of the varied disciplines within cognitive neuroscience, is the study of working memory”

It goes on to describe a “pyramid approach” to multidisciplinary work in this area, which chiefly involves the merging of cognitive psychology, computational science, neuroscience, and cognitive neuropsychiatry.

Shannon Moffett, author of The Three Pound Enigma [book website; Amazon], was kind enough to send us a copy of her book to review. To be honest, when I first took a look at the book, I was pretty sure that — while it might be a great, general-neuroscience-interest book for the public — it would certainly not appeal or be informative for the specialist in our Neurodudes audience. Now, after reading her wonderful book, I realize how wrong I was.

Full review is after the jump.
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