neurodudes

Salon has an interesting piece condemning a recent PBS show purportedly on Alzheimer’s treatment but really more of a sketchy informercial. The program concerns a neurologist with tenuous ties to UC Irvine who advocates SPECT (single photon emission computed tomograpy, a technique which, similar to PET, uses a radiotracer) and some unfounded preventative treatments for Alzheimer’s. The neurologist Bill Amen has appeared on many big-name media outlets including CNN, the Today Show, and Fox News (and the real sign of media success — Oprah) although his approach to Alzheimer’s detection and treatment is lacking in scientific credibility:

“SPECT scans are not sufficiently sensitive or specific to be useful in the diagnosis of A.D.,” neurologist Michael Greicius , who runs the Stanford University memory clinic, and has a special interest in the use of functional brain imaging in the diagnosis of A.D., tells me. “The PBS airing of Amen’s program provides a stamp of scientific validity to work which has no scientific validity.”

Continued pontification on neuroethics issues after the jump. (more…)

BioNumbers - The Database of Useful Biological Numbers

Here’s a neat new website. It’s a repository of quantitative information on biological things (eg. organisms, biomolecules, etc.) Some stuff I found while glancing through:

Number of mRNA/cell in E. coli: 138

Volume occupied by all RNA in E. coli: 6%

Average gene length in mammals: 16.6kb

Average gene length in nematode C. elegans:  4 kb

Mutation rate per genome per replication in humans: 0.16 mutation/genome/replication

Average time between blinks in humans: 2.8 sec

Amount of photons necessary to excite a cone in humans: 100

Citations are included for most numbers too. The database seems a little sparse on neuroscience topics, so go over and contribute some numbers!

A friend recently alerted me to The Journal of Visualized Experiments, a revolutionary way to present science by showing the actual experimental procedures. Poking around the site I already picked up tips for my own research just by watching others perform procedures that I do myself in the lab (eg. use Sparkle glass cleaner not just for objectives but also for sample coverglass, how to properly interpret the OD ratio on the spectrophotometer for RNA purity, etc.)

Click more to see some of my favorite videos on the site.

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As Neurodudes readers know, Ed Boyden has been blogging here at Neurodudes for quite a while. But now he has his own blog over at the MIT Tech Review. (We hope he continues to post here too!)

Also, congrats are in order: Ed recently was chosen to be one of the first to be awarded the NIH New Innovator Award!

Our brains have a lot of problems that need to be solved — now. And neurotechnology is a hot field. But what knowledge and skills do you study if you want to be a neurotechnologist? What problems are important, but also tractable within a reasonable timeframe? And, can you survive while climbing this possibly-very-high mountain?

A team of three academics at MIT and the University of Hong Kong is launching an international collaboration to create a set of novel courses to address this need. The first one, Neurotechnology Ventures, is being taught in Spring 2007 and focuses on neurotechnologies that are close to solving major human problems. The class explores the problems that neurotechnologists encounter when envisioning, planning, and building startups to bring neuroengineering innovations to the world.

Emphasizing the global nature of any modern neurotechnology, Neurotechnology Ventures will be videoconferenced between the U.S. and China, which is increasingly becoming a major neurotechnology player (including some very daring and scientifically interesting developments in fields such as human spinal cord regenerative medicine). Information will be posted online as the class evolves dynamically, to the web site HTTP://Neuroven.Media.MIT.edu. The goal is to open up this new field to the world, and see if we can solve the major problems of the brain in an open and efficient way.

Ed

UCSD’s Computational Neurobiology program just released a new website to herald a new year of research and graduate admissions. It seems to put a lot of emphasis on the students.

A New Psychology resource, community built by psychologists and trainees, to unify the body of psychology information in one place:

http://psychology.wikia.com/wiki/Main_Page

Check it out, and if it interests you, please contribute, or review it on your blog.

Tom Michael, Mostly Zen - site admin

The Journal of Physiology announced in the editorial in their recent issue that they have completed digitizing their archive all the way back to 1878, and that it’s now open-accessible from PubMed Central here. (Though I note that the PMC archive, contrary to the statements of the editorial, only goes back to 1904 at the moment.

This is great news, as a lot of classic neuroscience papers were published J Physiol in the 50s and 60s, and previously their online archive had only gone back to 1997 or so. See for example, the Hodgkin and Huxley 1952 papers (1, 2, 3, 4) and Hubel and Wiesel 1962.

-John O’Leary

What is NeuroWiki?

NeuroWiki is a wiki discussion forum about neuroscience research, especially theoretical, computational, and cognitive neuroscience. Neuroscience is an exploding field and it’s hard to keep track of. NeuroWiki will provide short, collaboratively written summaries of current research trends and ideas, with links to related papers and researchers — this will aid neuroscientists in keeping up with areas outside their specialty, and will allow researchers to learn about things related to their work that they would not have heard of otherwise. However, the best part of NeuroWiki will be the discussions spawned by these topics.

Like PLoS, NeuroWiki content will be “open content”, freely available for reuse in other projects.
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Eugene Izhekevich of The Neurosciences Institute has started a peer-reviewed wiki that looks similar to “The Digital Universe,” featured in Nature earlier this month. Most of the topics deal with computational neuroscience, and judging by his latest book his contributions will be worth reading.

-davematthews