June 14, 2010

Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

Yusuf Tufail, Alexei Matyushov, Nathan Baldwin, Monica L. Tauchmann, Joseph Georges, Anna Yoshihiro, Stephen I. Helms Tillery, William J. Tyler. Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits. Neuron, Volume 66, Issue 5, 681-694, 10 June 2010.

In motor cortex, ultrasound-stimulated neuronal activity was sufficient to evoke motor behaviors. Deeper in subcortical circuits, we used targeted transcranial ultrasound to stimulate neuronal activity and synchronous oscillations in the intact hippocampus. We found that ultrasound triggers TTX-sensitive neuronal activity in the absence of a rise in brain temperature (<0.01°C). Here, we also report that transcranial pulsed ultrasound for intact brain circuit stimulation has a lateral spatial resolution of approximately 2 mm and does not require exogenous factors or surgical invasion.


May 24, 2010

ConnectomeViewer – Multi-Modal Multi-Level Network and Neuroimaging Visualization and Analysis

Two neat tools concerned with the “connectome” (i.e. the pattern of connections in the nervous system):

Semantic wiki:
http://www.connectome.ch/wiki/Main_Page

Desktop viewer:
http://connectomeviewer.org/viewer “Multi-Modal Multi-Level Network and Neuroimaging Visualization and Analysis” (screencasts)


Allen Institute for Brain Science adds human brain data

Expression data is now available for over 60K gene probes over the entire human brain. Click here to access this monster data set!

More info after the jump.

Read on »


May 21, 2010

First organism from entirely synthesized genome

Craig Venter has made a bacterium from an entirely synthesized genome (link is nice summary in WSJ). Here’s the paper in Science. Now, that that’s taken care of… who will be the first to design a “synthetic biological neural circuit”?


May 20, 2010

Neural Interfaces workshop, conference, June 20-23 (student status letter due tomorrow)

1. Beyond Brain Machine Interface: From Senses to Cognition
Co-sponsored by IEEE Engineering in Medicine and Biology Society and Army Research Office
June 20, 2010, Long Beach, CA
Travel fellowships, poster abstracts, and registration:

http://tnsre.bme.jhu.edu/

2. 39th Neural Interfaces Conference
Co-sponsored by NIH Deep Brain Stimulation Consortium
June 21-23, 2010, Long Beach, CA
Free registration for students (Faculty Advisor letter due May 21)
Program, registration, and further information:

http://www.neuralinterfaces2010.com/

Read on »


May 19, 2010

audeo (not news)

http://www.theaudeo.com/?action=technology

Detects subthreshold electrical activity from laryngeal muscles and attempts to recognize words from it, allowing a sort of silent cell phone, as well as command-and-control applications. They have a technical manual on the website, as well as a video demo of a “voiceless phone call”.


May 16, 2010

The evolutionary psychology of war

Nothing too shocking here for students of evolutionary psychology but it’s always interesting to see real world examples of how our shared behavior. There is a new book by Sebastian Junger called War, in which he recounts how men do not fight for larger ideological goals (eg. “a safer Iraq”, “finding Bin Laden”) but instead they can overcome fears because “they’re more concerned about their brothers than what happens to themselves individually”. Here’s Junger on Good Morning America:

After the jump some more from Junger and a nice talk from Robert Sapolsky about similar behaviors in chimps.

Read on »


May 14, 2010

Dendritic organization of sensory input to cortical neurons in vivo

Jia, H., Rochefort, N., Chen, X., & Konnerth, A. (2010). Dendritic organization of sensory input to cortical neurons in vivo Nature, 464 (7293), 1307-1312 DOI: 10.1038/nature08947

Consider a a cortical neuron in V1, layer 2/3, whose output shows sharp orientation tuning. What are the orientation tunings of the most important inputs to that neuron? What is the spatial distribution of these inputs in the neuron’s dendritic tree?

Read on »


May 12, 2010

Mosaic genetic methods (not news)

Mosaic (genetics) – Wikipedia, the free encyclopedia.

This has been done for quite awhile but I thought I’d post about it because I think it’s a neat idea — genetically manipulate experimental subjects so that only some cells have the mutation, while others are wild-type.

READ MORE: Genetic

May 11, 2010

Big Dog: rough-terrain robot

Movie of a load-bearing dog-like robot that can’t be kicked over, that can walk in the woods up a hill, sometimes recover from slipping on ice, walk over a pile of concrete blocks, and run.

http://www.bostondynamics.com/dist/BigDog.wmv

Read on »

READ MORE: Robotics

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